Cognitive decline, a pressing concern in contemporary society, affects millions of individuals and their families, leading to significant emotional, social, and economic burdens. As the population ages, the prevalence of neurodegenerative conditions such as Alzheimer’s disease and other forms of dementia has intensified the urgency for effective therapeutic interventions. Research has increasingly illuminated the multifaceted nature of cognitive decline, revealing that it is not merely an inevitable consequence of aging, but rather a complex interplay of biological, psychological, and environmental factors. This article seeks to explore various therapeutic approaches tailored to mitigate cognitive decline, including cognitive training, psychosocial interventions, and pharmacological treatments, while examining their efficacy and applicability in real-world contexts. By delving into the latest advancements and ongoing studies, the discussion aims to inform and inspire a deeper understanding of how innovative therapies can enhance cognitive resilience and improve the quality of life for those affected. Aspect Key Takeaway Therapy for Cognitive Decline Effective therapy for cognitive decline combines cognitive training, lifestyle changes, pharmacological treatments, and social support to improve quality of life and cognitive resilience. Evidence-Based Approaches Personalized interventions, including cognitive exercises and dietary strategies like the Mediterranean diet, have shown significant benefits in